Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells
FC Roth, JE Mulder, JF Brien, T Takahashi… - Chemico-biological …, 2013 - Elsevier
The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is
characterized by cell death in the lungs, followed by inflammation and fibrosis. AM's major
metabolite, desethylamiodarone (DEA), has a greater toxic potency than AM and it has been
suggested that DEA may act synergistically with AM to cause lung toxicity. The objective of
this study was to determine the type of cytotoxic interaction between AM and DEA in HPL1A …
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is
characterized by cell death in the lungs, followed by inflammation and fibrosis. AM's major
metabolite, desethylamiodarone (DEA), has a greater toxic potency than AM and it has been
suggested that DEA may act synergistically with AM to cause lung toxicity. The objective of
this study was to determine the type of cytotoxic interaction between AM and DEA in HPL1A …
以上显示的是最相近的搜索结果。 查看全部搜索结果